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The Cubs and Padres are no strangers to meeting in October.
For the second straight year, these two teams are facing off in the NL wild-card round, with Chicago looking to repeat last season’s postseason success against San Diego.
Can the Padres flip the script in 2026?
Let’s check out the odds for the series at DraftKings Sportsbook as of Sept. 30, as well as what to know.
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NL Wild Card: Padres vs. Cubs
Series Winner
Padres: -450 (bet $10 to win $12.22 total)
Cubs: +340 (bet $10 to win $44 total)
Game 1 — SD 9, CHI 0
Spread: Padres -1.5 (SD covers)
Moneyline: Padres -130, Cubs +108 (SD wins)
O/U: 7.5 (Over hits)
Game 2 (Sept. 30)
Spread: Padres -1.5
Moneyline: Padres -137, Cubs +113
O/U: 7
Here’s what to know about the Padres-Cubs odds:
Season Series: During the regular season this year, the Cubs went 5-1 against the Padres in six games. Playing at Petco Park in late April, the Cubs took two of three games (losing 9-7 on April 27, then winning 8-3 on April 28 and 5-4 on April 29). The Cubs then completed a three-game sweep at Wrigley Field from June 29 to July 1, winning by scores of 3-2, 9-7, and a dominant 23-3 blowout in the finale.
Game 1: Things got ugly for the Cubs fast in Game 1. San Diego scored two in the first, one apiece in the third and fourth, and three in the fifth, before capping it off with one more run in the seventh. Michael King was lights out, allowing one hit in seven innings and striking out eight. The Padres’ superstar bats also came to play, as Fernando Tatis Jr. and Manny Machado both hit solo jacks in the first inning to set the tone at Petco Park.
Game 2 will go down Wednesday, as San Diego looks to make quick work of Chicago.
